野生灰鼠行为选择与初次和二次免疫反应之间的关系

Relationship between behavioral selection and primary and secondary immune response in wild gray rats.

作者信息

Os'kina I N, Shikhevich S G, Gulevich R G

机构信息

Institute of Cytology and Genetics, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk.

出版信息

Bull Exp Biol Med. 2003 Oct;136(4):404-7. doi: 10.1023/b:bebm.0000010964.04866.ab.

DOI:10.1023/b:bebm.0000010964.04866.ab

PMID:14714095

Abstract

The main characteristics of primary and secondary immune response (number of antibody producing cells and the amount of produced antibodies) are reduced in rats selected by elimination of aggressive behavior in comparison with animals selected by stimulation of this behavior. In parallel, the reaction of the pituitary-adrenal system during immune response was modified in these rats. Presumably, the differences in immune reactions of rats selected by contrast behavior are determined by changes in reactivity of the pituitary-adrenal system to stress and immune stimulation during selection.

摘要

与通过刺激攻击行为选择的动物相比，通过消除攻击行为选择的大鼠的初次和二次免疫反应的主要特征（产生抗体的细胞数量和产生的抗体量）有所降低。同时，这些大鼠免疫反应期间垂体 - 肾上腺系统的反应发生了改变。据推测，通过相反行为选择的大鼠免疫反应的差异是由垂体 - 肾上腺系统在选择过程中对应激和免疫刺激的反应性变化所决定的。