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[大脑神经化学系统在改变用于行为学研究的灰色大鼠垂体-肾上腺系统反应性中的作用]

[Role of the brain neurochemical systems in altering the reactivity of the hypophyseal-adrenal system in the gray rat selected for behavior].

作者信息

Dygalo N N, Shishkina G T, Borodin P M, Naumenko E V

出版信息

Zh Evol Biokhim Fiziol. 1985 Jul-Aug;21(4):342-7.

PMID:4050211
Abstract

Studies have been made of the interrelationship between brain monoaminergic system and pituitary-adrenal function in two groups of the grey rat Rattus norvegicus Berk. One group consisted of non-aggressive rats selected for lack of agonism towards experimentator, the other one included aggressive animals. Domesticated animals exhibited the decreased reaction of the pituitary-adrenocortical complex to emotional stress as well as the decreased response of the endocrine system during stimulation of noradrenaline or serotonin mechanisms of the brain. In addition, noradrenaline and serotonin content of the brain decreased in domesticated rats during emotional stress to a lower extent, as compared to that in aggressive ones. Therefore, one of the sources of correlational changes in the activity of the pituitary-adrenocortical complex during selection for domesticated behaviour is the effect of selection on neurochemical, in particular monoaminergic systems of the brain.

摘要

对两组褐家鼠(Rattus norvegicus Berk)的大脑单胺能系统与垂体 - 肾上腺功能之间的相互关系进行了研究。一组由对实验者缺乏攻击性而挑选出的非攻击性大鼠组成,另一组包括攻击性动物。驯化动物的垂体 - 肾上腺皮质复合体对情绪应激的反应降低,并且在刺激大脑去甲肾上腺素或血清素机制时内分泌系统的反应也降低。此外,与攻击性大鼠相比,驯化大鼠在情绪应激期间大脑中去甲肾上腺素和血清素含量降低的程度较小。因此,在选择驯化行为过程中,垂体 - 肾上腺皮质复合体活动相关性变化的一个来源是选择对神经化学,特别是大脑单胺能系统的影响。

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Zh Evol Biokhim Fiziol. 1985 Jul-Aug;21(4):342-7.
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