Xie Rui-qin, Du Jun, Hao Yu-ming
Department of Cardiology, Second Hospital of Hebei Medical University, Shijiazhuang 050000.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2003 Dec;23(12):895-7.
To explore the protective effect and the mechanism of Puerarin Injection (PI) on myocardial ischemia reperfusion in patients with coronary heart disease (CHD) and angina pectoris (AP).
Seventy-eight patients with AP planned to receive the PTCA and stenting treatment were randomly divided and single-blindedly into the conventional group and the PI group. Based on the conventional treatment and pre-operational preparation, the PI group was given 200 ml of PI by intravenous dripping once a day, beginning from one week before operation, but to the conventional group, normal saline was given for instead. The condition of AP attack in balloon dilatatory stage of PTCA was observed and change of ST segment of ECG detected by a 12-lead ECG monitor. The blood levels of von Willebrand factor (vWF:Ag), nitric oxide (NO) and endothelin-1 (ET-1) were also observed before and after treatment.
As compared with those in the conventional group, number of patients having AP attack and ST segment change in PTCA process was lessened in the PI group, with blood levels of vWF:Ag and ET-1 obviously lower, and NO content obviously higher than those in the conventional group,
PI could protect the myocardium in 2-3 days after ischemia reperfusion, one of the possible reasons is that PI can simulate the late phase of ischemic preconditioning, which may be related to its effect in lowering plasma vWF:Ag and ET-1, and increasing the serum NO content.
探讨葛根素注射液（PI）对冠心病（CHD）心绞痛（AP）患者心肌缺血再灌注的保护作用及其机制。
将78例计划接受PTCA及支架置入治疗的AP患者随机单盲分为常规组和PI组。在常规治疗及术前准备的基础上，PI组于术前1周开始每天静脉滴注200ml PI，常规组则给予生理盐水替代。观察PTCA球囊扩张阶段AP发作情况，并用12导联心电图监测仪检测心电图ST段变化。同时观察治疗前后血管性血友病因子（vWF:Ag）、一氧化氮（NO）和内皮素-1（ET-1）的血药浓度。
与常规组相比，PI组PTCA过程中AP发作次数及ST段变化减少，vWF:Ag和ET-1血药浓度明显低于常规组，NO含量明显高于常规组。
PI可在缺血再灌注后2~3天保护心肌，其可能原因之一是PI可模拟缺血预处理晚期，这可能与其降低血浆vWF:Ag和ET-1、增加血清NO含量有关。
