Zamiatinin A A
Bakh Institute of Biochemistry, Russian Academy of Sciences, Leninskii pr. 33, Moscow, 119071 Russia.
Biofizika. 2003 Nov-Dec;48(6):1030-9.
A number of physical problems arising in studies of the relationship between the structure and function of natural peptide molecules consisting of 2-50 amino acid residues were considered. Among these are the determination of functionally significant sizes of molecules and their configurations, a search for general principles of classification, and a study of the mechanisms of delivery of oligopeptide molecules and their binding to receptor structures. The natural concentrations and coefficients of diffusion of oligopeptides were compared with the time of their real functioning. The solubility of these and other problems was assessed.
考虑了在对由2至50个氨基酸残基组成的天然肽分子的结构与功能之间关系的研究中出现的一些物理问题。其中包括确定分子功能上重要的大小及其构型，寻找分类的一般原则，以及研究寡肽分子的传递机制及其与受体结构的结合。将寡肽的天然浓度和扩散系数与其实际发挥功能的时间进行了比较。评估了这些及其他问题的可解性。
