Voss Linda D, Kirkby Joanne, Metcalf Brad S, Jeffery Alison N, O'Riordan Christina, Murphy Michael J, Wilkin Terence J
The EarlyBird Research Centre, Peninsula Medical School, Plymouth, UK.
J Pediatr Endocrinol Metab. 2003 Dec;16(9):1211-24. doi: 10.1515/jpem.2003.16.9.1211.
For a decade or more, poor nutrition during gestation, expressed as low weight at birth, was held to be the factor responsible for insulin resistance later in life. Birth weights, however, are rising and insulin resistant states, such as diabetes mellitus, faster still. Alternative explanations are needed to explain insulin resistance in contemporary industrialised populations. EarlyBird is a non-intervention prospective cohort study that asks the question 'Which children develop insulin resistance, and why?' It is unique in taking serial blood samples from a young age with which to monitor the behaviour of insulin resistance and its metabolic correlates. This, the baseline report of the EarlyBird Study, describes the rationale, design and methodology of the study, and the profile of the population at entry. It situates the anthropometric, physical activity and dietary status of the EarlyBird children and provides a detailed metabolic profile of the British 5 year-old in the year 2000.
十年来甚至更长时间，孕期营养不良表现为出生体重低，被认为是导致日后生活中胰岛素抵抗的因素。然而，出生体重在上升，而胰岛素抵抗状态，如糖尿病，上升得更快。需要其他解释来阐释当代工业化人群中的胰岛素抵抗现象。“早起鸟”是一项非干预性前瞻性队列研究，它提出了“哪些儿童会出现胰岛素抵抗，原因是什么？”这一问题。该研究的独特之处在于从幼年起采集系列血样，用以监测胰岛素抵抗及其代谢相关指标的变化情况。这份“早起鸟研究”的基线报告描述了该研究的基本原理、设计和方法，以及入组人群的概况。它阐述了“早起鸟”儿童的人体测量学、身体活动和饮食状况，并提供了2000年英国5岁儿童详细的代谢概况。
