Zotter Heinz, Kerbl Reinhold, Gallistl Siegfried, Nitsche Hilde, Borkenstein Martin
Department of Pediatrics, University of Graz, Graz, Austria.
J Pediatr Endocrinol Metab. 2003 Dec;16(9):1257-62. doi: 10.1515/jpem.2003.16.9.1257.
The aim of this study was to determine whether infrared thermography before and after challenge of the lower leg in cold water may be a useful tool to detect abnormalities in skin blood flow in adolescent asymptomatic patients with type 1 diabetes mellitus (DM1) and to assess the optimal setting of skin temperature measurements. Twenty-five adolescents (10 female, 15 male, mean age 21.2 +/- 6.2 years, body mass index [BMI] 23.0 +/- 2.1 kg/m2) with a duration of DMI of 13.8 +/- 5.4 years and mean HbA1c levels 8.5 +/- 1.3% were compared to age- and sex-matched controls (BMI 22.9 +/- 2.2 kg/m2). Seven defined sites of the lower leg were assessed by infrared thermography before and for 10 min after exposure of the leg to 14 degrees C cold water. As skin temperature before exposure to cold water differs from individual to individual and basal temperature was significantly warmer in patients at the tip of the first (p < 0.05) and fifth (p < 0.05) toe, the rewarming index was calculated in order to compare data. Rewarming indexes of skin temperature during the whole measurement procedure (0-10 min) were significantly lower at the tip of the first (p < 0.05) and fifth (p < 0.01) toes and from minute 2-10 also at the inner ankle (p < 0.05) in patients compared to healthy controls. Rewarming indexes of the other four sites were not significantly different between patients and controls. Infrared thermography of the lower leg after cold water exposure is an easily applicable method and a useful tool to detect abnormalities of skin blood flow in adolescents with DM1 especially at the tips of the first and fifth toes and the inner ankle.
本研究的目的是确定在冷水刺激小腿前后进行红外热成像是否可能是一种有用的工具，用于检测1型糖尿病（DM1）无症状青少年患者皮肤血流异常，并评估皮肤温度测量的最佳设置。将25名青少年（10名女性，15名男性，平均年龄21.2±6.2岁，体重指数[BMI]23.0±2.1kg/m²）与年龄和性别匹配的对照组（BMI 22.9±2.2kg/m²）进行比较，这些青少年DM1病程为13.8±5.4年，平均糖化血红蛋白（HbA1c）水平为8.5±1.3%。在小腿暴露于14摄氏度冷水之前和之后10分钟，通过红外热成像评估小腿的七个特定部位。由于暴露于冷水之前的皮肤温度因人而异，且患者第一趾尖（p<0.05）和第五趾尖（p<0.05）的基础温度明显较高，因此计算复温指数以比较数据。与健康对照组相比，患者在整个测量过程（0-10分钟）中第一趾尖（p<0.05）和第五趾尖（p<0.01）以及第2-10分钟内踝处（p<0.05）的皮肤温度复温指数显著较低。患者和对照组之间其他四个部位的复温指数没有显著差异。冷水暴露后小腿的红外热成像是一种易于应用的方法，是检测DM1青少年皮肤血流异常的有用工具，尤其是在第一和第五趾尖以及内踝处。
