由3α,6α-二羟基-5β-孕烷-20-酮（二醇酮）合成3α,6α,17α-三羟基-5β-孕烷-20-酮（三醇酮）。
A synthesis of 3alpha,6alpha,17alpha-trihydroxy-5beta-pregnan-20-one (triolone) from 3alpha,6alpha-dihydroxy-5beta-pregnan-20-one (diolone).
作者信息
Mazurkiewicz Witold
机构信息
Department of Organic Chemistry, Faculty of Chemistry, Rzeszów University of Technology, 6 Powstańców Warszawy Av., 35-011 Rzeszów, Poland.
出版信息
Acta Pol Pharm. 2003 Jul-Aug;60(4):281-4.
PMID:14714856
Abstract
An optimization of synthesis of 3alpha,6alpha,17alpha-trihydroxy-5beta-pregnan-20-one from 3alpha,6alpha-dihydroxy-5beta-pregnan-20-one by subsequent acetylenolization, epoxidation, and ring opening reactions has been described. Epoxide hydrolysis at different temperatures (room and at boiling) has also been investigated.
摘要
已描述了从3α,6α-二羟基-5β-孕烷-20-酮通过后续乙炔醇化、环氧化和开环反应合成3α,6α,17α-三羟基-5β-孕烷-20-酮的合成优化方法。还研究了在不同温度（室温及沸腾温度）下环氧化物的水解情况。
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