Peterson P L, Howe F A, Clark C A, Axford J S
Lupus Research Unit, St Thomas' Hospital, London, UK.
Lupus. 2003;12(12):897-902. doi: 10.1191/0961203303lu499oa.
Neuropsychiatric symptoms are common in systemic lupus erythematosus (SLE) but are poorly understood. Although there is a wide spectrum of clinical manifestations, brain histology often simply shows a bland vasculopathy. Magnetic resonance techniques such as magnetic resonance spectroscopy, magnetization transfer imaging and diffusion weighted imaging have been used to try to improve our understanding of the pathophysiological mechanisms involved in neuropsychiatric lupus (NPSLE). This article reviews the current literature on the use of these techniques and their possible future role as diagnostic tools in NPSLE.
神经精神症状在系统性红斑狼疮（SLE）中很常见，但人们对此了解甚少。尽管临床表现多种多样，但脑部组织学检查通常仅显示轻度血管病变。磁共振波谱、磁化传递成像和扩散加权成像等磁共振技术已被用于尝试增进我们对神经精神性狼疮（NPSLE）所涉及的病理生理机制的理解。本文综述了有关这些技术应用的当前文献及其未来作为NPSLE诊断工具可能发挥的作用。
