Takahashi Toru, Hatao Katsuhiro, Yamashita Yoshimi, Tanizawa Yukio
Division of Molecular Analysis of Human Disorders, Department of Bio-signal Analysis, Yamaguchi University Graduate School of Medicine, Ube.
Intern Med. 2003 Dec;42(12):1197-201. doi: 10.2169/internalmedicine.42.1197.
A 21-year-old woman with Cushing's syndrome presented with a mediastinal tumor. Ectopic ACTH syndrome was diagnosed and the tumor was resected. The histopathological diagnosis was thymic atypical carcinoid. Despite all tumor lesions having been resected, the tumor relapsed and multiple metastatic lesions grew aggressively. Combination chemotherapy with cisplatin and etoposide (VP16) was administered to control tumor progression, and achieved marked therapeutic effects. Maintenance chemotherapy with carboplatin and VP16 achieved long-term tumor control. This case indicates that some patients with atypical carcinoid tumor are good responders to chemotherapy with platinum agents and VP16.
一名患有库欣综合征的21岁女性出现纵隔肿瘤。诊断为异位促肾上腺皮质激素综合征并切除了肿瘤。组织病理学诊断为胸腺非典型类癌。尽管所有肿瘤病灶均已切除，但肿瘤仍复发，且多个转移病灶迅速生长。给予顺铂和依托泊苷（VP16）联合化疗以控制肿瘤进展，并取得了显著的治疗效果。卡铂和VP16维持化疗实现了肿瘤的长期控制。该病例表明，一些非典型类癌肿瘤患者对铂类药物和VP16化疗反应良好。
