Arya Prabhat, Durieux Patricia, Chen Zai-Xin, Joseph Reni, Leek Donald M
Chemical Biology Program, Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, Ottawa, Ontario, Canada, K1A 0R6.
J Comb Chem. 2004 Jan-Feb;6(1):54-64. doi: 10.1021/cc034053z.
A diversity-oriented solution and solid-phase synthesis of tetrahydroquinoline-based tricyclic derivatives has been achieved from enantiomerically pure, natural product-like bicyclic scaffold. The solution synthesis of enantiopure bicyclic scaffold was developed by asymmetric hetero Michael reaction. Our approach for the synthesis of polycyclic derivatives utilized regio- and stereoselective hetero Michael reaction and ring-closing metathesis as key steps in solution and on solid phase.
从对映体纯的、类似天然产物的双环骨架出发，实现了基于四氢喹啉的三环衍生物的多样性导向合成及固相合成。对映体纯双环骨架的溶液合成是通过不对称杂迈克尔反应开发的。我们合成多环衍生物的方法利用区域和立体选择性杂迈克尔反应以及闭环复分解反应作为溶液和固相中的关键步骤。
