通过偏振敏感光学相干断层扫描术测定烧伤深度

Determination of burn depth by polarization-sensitive optical coherence tomography.

作者信息

Srinivas Shyam M, de Boer Johannes F, Park Hyle, Keikhanzadeh Kourosh, Huang Huai-en L, Zhang Jun, Jung Woong Qyu, Chen Zhongping, Nelson J Stuart

机构信息

Beckman Laser Institute, Department of Biomedical Engineering and Surgery, University of California-Irvine, Irvine, CA 92612, USA.

出版信息

J Biomed Opt. 2004 Jan-Feb;9(1):207-12. doi: 10.1117/1.1629680.

DOI:10.1117/1.1629680

PMID:14715075

Abstract

An assessment of burn depth is a key step in guiding the treatment of patients who have sustained thermal injuries. Polarization-sensitive optical coherence tomography (PS-OCT) might eventually provide the physician with a quantitative estimate of actual burn depth. Burns of various depths were induced by contacting rat skin with a brass rod preheated to 75 degrees C for 5, 15, or 30 s. Thermal injury denatured the collagen in the skin, and PS-OCT imaged the resulting reduction of birefringence through the depth-resolved changes in the polarization state of light propagated and reflected from the sample. Stokes vectors were calculated for each point in the PS-OCT images and the reduction in the rate of phase retardation between two orthogonal polarizations of light (deg/microm) was found to show a consistent trend with burn exposure time. PS-OCT is a noninvasive technique with potential to give the physician the information needed to formulate an optimal treatment plan for burn patients.

摘要

评估烧伤深度是指导热损伤患者治疗的关键步骤。偏振敏感光学相干断层扫描（PS-OCT）最终可能为医生提供实际烧伤深度的定量估计。通过将预热至75摄氏度的黄铜棒与大鼠皮肤接触5、15或30秒，诱导出不同深度的烧伤。热损伤使皮肤中的胶原蛋白变性，PS-OCT通过对从样品传播和反射的光的偏振状态进行深度分辨变化，对由此产生的双折射降低进行成像。计算PS-OCT图像中每个点的斯托克斯矢量，发现两个正交偏振光之间的相位延迟率降低（度/微米）与烧伤暴露时间呈现出一致的趋势。PS-OCT是一种非侵入性技术，有可能为医生提供制定烧伤患者最佳治疗方案所需的信息。