Boeckstyns M E, Backer M, Petersen E M, Høj I, Albrechtsen H, Andersen H B
Rigshospitalet Department of Orthopedics, Copenhagen, Denmark.
Acta Orthop Scand. 1992 Dec;63(6):658-60. doi: 10.1080/17453679209169730.
In a blinded, placebo-controlled study, the nonsteroidal antiinflammatory drug piroxicam, in combination with the partial morphine agonist/antagonist buprenorphine, was compared with buprenorphine alone for analgesic effect and side-effects in a 10-day period following total replacement of the hip or knee. 117 patients entered and 81 completed the study. The patients receiving piroxicam consumed less buprenorphine. There were no differences concerning side-effects between the two treatment groups, apart from a tendency towards less nausea after the third postoperative day in the group receiving piroxicam.
在一项双盲、安慰剂对照研究中，将非甾体抗炎药吡罗昔康与部分吗啡激动剂/拮抗剂丁丙诺啡联合用药，与单独使用丁丙诺啡比较，观察其在全髋关节或全膝关节置换术后10天内的镇痛效果和副作用。117例患者入组，81例完成研究。服用吡罗昔康的患者丁丙诺啡用量较少。除了术后第三天后服用吡罗昔康的组恶心倾向较轻外，两个治疗组在副作用方面没有差异。
