Effect of abciximab on prothrombin activation and thrombin generation in patients with acute myocardial infarction also receiving reteplase.

作者信息

Merlini Piera Angelica, Repetto Alessandra, Andreoli Anna Maria, Ricci Silvio, Lombardi Alessandro, Finardi Angelo, Dipasquale Giuseppe, Lamponi Monica, Mannucci Pier Mannuccio, Ardissino Diego

机构信息

Division of Cardiology, Ospedale Niguarda, Milan, Italy.

出版信息

Am J Cardiol. 2004 Jan 15;93(2):195-8. doi: 10.1016/j.amjcard.2003.09.036.

Fibrinolysis in acute myocardial infarction activates blood coagulation and may favor reocclusion or ischemic complications. The aim of the GUSTO V Italian Hematologic Substudy was to compare the effects of full-dose reteplase on coagulation activation markers with those of half-dose reteplase combined with full-dose abciximab, a platelet glycoprotein IIb/IIIa receptor antagonist, during the early phase after acute myocardial infarction.