Frohlich E D
Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121.
Am J Cardiol. 1992 Dec 21;70(21):7I-9I. doi: 10.1016/0002-9149(92)90259-2.
The potential role that calcium antagonists play toward enhancing cardioprotection is discussed, while recognizing that they are much more heterogeneous than other classes of antihypertensive or antianginal agents. Similarities and differences between the mechanisms of action and clinical effects of individual drugs are discussed. Among these is the ability of some of them to reduce left ventricular hypertrophy rapidly while simultaneously and uniquely increasing right ventricular wall thickness. Although the clinical importance of this as a potential cardioprotective effect is undetermined, the renal protective effect of some calcium antagonists is discussed in detail.
本文讨论了钙拮抗剂在增强心脏保护方面的潜在作用，同时认识到它们比其他类别的抗高血压或抗心绞痛药物具有更大的异质性。文中还讨论了个别药物的作用机制和临床效果之间的异同。其中一些药物能够迅速减轻左心室肥厚，同时独特地增加右心室壁厚度。尽管这作为一种潜在心脏保护作用的临床重要性尚未确定，但本文详细讨论了一些钙拮抗剂的肾脏保护作用。
