Raina Arun K, Zhu Xiongwei, Shimohama Shun, Perry George, Smith Mark A
Department of Pathology, Case Western Reserve University, Cleveland, Ohio, USA.
Cell Biochem Biophys. 2003;39(3):249-55. doi: 10.1385/CBB:39:3:249.
The mechanisms underlying the selective neuronal death in Alzheimer's disease are largely unresolved. Nonetheless, it is apparent that the environment of the diseased brain is extremely rich in pro-apoptotic stimuli and that these lead to an activation of the apoptotic death cascade. However, there is surprisingly little evidence for the completion of the death pathway indicating that the apoptotic death program is terminated by a mechanism termed abortosis. This review discusses the concept of abortosis in relation to Alzheimer's disease.
阿尔茨海默病中选择性神经元死亡的潜在机制在很大程度上尚未得到解决。尽管如此，很明显，患病大脑的环境中促凋亡刺激极其丰富，并且这些刺激会导致凋亡死亡级联反应的激活。然而，令人惊讶的是，几乎没有证据表明死亡途径已经完成，这表明凋亡死亡程序是通过一种称为流产凋亡的机制终止的。本综述讨论了与阿尔茨海默病相关的流产凋亡概念。
