Tavernier E, Thomas X
Service d'Hematologie Clinique, Hopital Edouard Herriot, 69437 Lyon cedex 03, France.
Indian J Cancer. 2003 Oct-Dec;40(4):140-3.
We described a 41-year-old patient with acute promyelocytic leukemia (APL) who experienced two successive relapses: one after all-trans retinoic acid (ATRA) treatment and chemotherapy, and another after ATRA treatment and chemotherapy, followed by autologous peripheral blood stem cell transplantation. A third complete remission (CR) was achieved with arsenic trioxide (As2O3) therapy. Mini-transplantation was performed as consolidation therapy. While the patient was in molecular remission at the beginning of conditioning regimen, a new relapse arose after transplantation at time of cell recovery. This raises a potential relationship between relapse and the severe immunosuppression induced by mini-transplantation. To our knowledge, this is the first description of a mini-allograft in an APL patient achieving molecular remission after As2O3 therapy.
我们描述了一名41岁的急性早幼粒细胞白血病（APL）患者，该患者经历了两次连续复发：一次是在全反式维甲酸（ATRA）治疗和化疗后，另一次是在ATRA治疗和化疗后，接着进行了自体外周血干细胞移植。通过三氧化二砷（As2O3）治疗实现了第三次完全缓解（CR）。进行了小型移植作为巩固治疗。虽然患者在预处理方案开始时处于分子缓解状态，但在移植后细胞恢复时出现了新的复发。这提示了复发与小型移植诱导的严重免疫抑制之间可能存在的关系。据我们所知，这是首次描述在As2O3治疗后实现分子缓解的APL患者中进行小型同种异体移植的情况。
