Lenchik Leon, Shi Rong, Register Thomas C, Beck Stephanie R, Langefeld Carl D, Carr J Jeffrey
Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston-Salem, NC 27157, USA.
J Comput Assist Tomogr. 2004 Jan-Feb;28(1):134-9. doi: 10.1097/00004728-200401000-00023.
To develop a method and evaluate the performance of thoracic bone mineral density (BMD) measurement using cardiac gated quantitative computed tomography (QCT).
A total of 762 participants (57% female) with a mean age of 61 years had a CT examination of the heart using prospective cardiac gating. A subset of 443 participants had replicate CT examinations of the heart. Another, nonindependent subset of 464 participants had CT examination of the abdomen. A QCT calibration phantom was included in all scans. Trabecular BMD was measured in the thoracic (T6-T11) and lumbar (T11-L4) spine. Tests of calibration and refinement and simple correlations between replicate thoracic BMD measurements and between thoracic and lumbar BMD measurements were calculated.
There was high correlation between replicated thoracic BMD measurements in men (r = 0.995, P < 0.0001) and in women (r = 0.995, P < 0.0001). There was high correlation between thoracic and lumbar BMD in men (r = 0.90, P < 0.0001) and in women (r = 0.94, P < 0.0001). The mean BMD was higher in the thoracic spine than the lumbar spine in men (137.58 mg/cm3 vs. 126.94 mg/cm3, P < 0.0001) and in women (152.07 mg/cm3 vs. 133.44 mg/cm3, P < 0.0001). In both genders, thoracic and lumbar BMD was inversely associated with age (all P < 0.05).
Cardiac gated CT, primarily intended for measurement of coronary vascular calcium, can be used to measure thoracic BMD with high precision. Thoracic BMD measurements using this method are highly correlated with QCT measurements in the lumbar spine.
开发一种使用心脏门控定量计算机断层扫描（QCT）测量胸椎骨密度（BMD）的方法并评估其性能。
共有762名参与者（57%为女性），平均年龄61岁，采用前瞻性心脏门控进行心脏CT检查。443名参与者的子集进行了心脏CT重复检查。另一个由464名参与者组成的非独立子集进行了腹部CT检查。所有扫描均包含QCT校准体模。测量胸椎（T6 - T11）和腰椎（T11 - L4）的小梁骨密度。计算校准和细化测试以及胸椎BMD重复测量值之间以及胸椎和腰椎BMD测量值之间的简单相关性。
男性重复测量的胸椎BMD之间（r = 0.995，P < 0.0001）以及女性之间（r = 0.995，P < 0.0001）存在高度相关性。男性胸椎和腰椎BMD之间（r = 0.90，P < 0.0001）以及女性之间（r = 0.94，P < 0.0001）存在高度相关性。男性胸椎的平均BMD高于腰椎（137.58 mg/cm³对126.94 mg/cm³，P < 0.0001），女性也是如此（152.07 mg/cm³对133.
