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不同温度的生理盐水冲洗对大鼠关节软骨表面的影响:一项实验研究

The effect of normal saline irrigation at different temperatures on the surface of articular cartilage: an experimental study in the rat.

作者信息

Cheng Shun-Chien, Jou I-Ming, Chern Tai-Chang, Wang Ping-Hui, Chen Wen-Chau

机构信息

Department of Orthopedic Surgery, Chi-Mei Foundation Medical Center, Yung Kang City, Tainan County, Taiwan.

出版信息

Arthroscopy. 2004 Jan;20(1):55-61. doi: 10.1016/j.arthro.2003.10.012.

DOI:10.1016/j.arthro.2003.10.012
PMID:14716280
Abstract

PURPOSE

To determine, with an electron microscope, the effects of irrigation fluid at different temperatures on the surface of articular cartilage. TYPE OD STUDY: Experimental in vivo study.

METHODS

With a scanning electron microscope, we investigated the effect of 2 hours of irrigation with normal saline at 3 different temperatures (4 degrees C, 25 degrees C, and 37 degrees C) on articular hyaline cartilage in an in vivo rat knee model study. The contralateral knees were used as controls. We then compared the results.

RESULTS

Specimens irrigated with cold (4 degrees C) fluid seemed to show the most uneven surface and apparent fibril exposure. Those irrigated with fluid close to body temperature (37 degrees C) showed the most even surface without fibril exposure.

CONCLUSIONS

Although further work is needed to evaluate the long-term effects, using warm irrigation fluid to maintain the intra-articular environment at a more physiologically normal temperature may help reduce damage to cartilage during irrigation.

摘要

目的

通过电子显微镜确定不同温度的冲洗液对关节软骨表面的影响。研究类型:体内实验研究。

方法

在一项体内大鼠膝关节模型研究中,我们使用扫描电子显微镜研究了在3种不同温度(4℃、25℃和37℃)下用生理盐水冲洗2小时对关节透明软骨的影响。对侧膝关节用作对照。然后我们比较了结果。

结果

用冷(4℃)液体冲洗的标本表面似乎最不均匀,且有明显的纤维暴露。用接近体温(37℃)的液体冲洗的标本表面最均匀,没有纤维暴露。

结论

尽管需要进一步研究来评估长期影响,但使用温热冲洗液将关节内环境维持在更生理正常的温度可能有助于减少冲洗过程中对软骨的损伤。

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