Furák József, Troján Imre, Szôke Tamás, Tiszlavicz László, Morvay Zita, Balogh Adám
Sebészeti Klinika, Szegedi Tudományegyetem, Szeged 6720, Hungary.
Magy Onkol. 2003;47(4):349-53. Epub 2004 Jan 11.
One of the subtypes of pulmonary adenocarcinoma, bronchioloalveolar carcinoma (BAC), is mentioned as the lung cancer of non-smoking women. We have studied the clinical characteristics of BAC and its surgical treatment.
Between 1992 and 2001, lung resections for BAC were performed on 101 patients: 55 men and 46 women, average age 59.7 years. Thirty-two of the patients were non-smokers, and 69 were active smokers. In 1992 the incidence of BAC was 17.5% of all adenocarcinomas, whereas in 2001 it had risen to 51.6%. The operations involved 76 lobectomies, 12 pulmonectomies, 11 wedge resections and 2 explorative thoracotomies.
The surgical mortality was 0.9%. The final histologic findings revealed that 82.1% of the tumours were in stages I or II, with 33.7% of the total in stage I/A. The average 5-year survival was 64.3%. Survival for women 75%, was significantly better than that for men, 51% (p=0.045). A significant difference was not found in the 5-year survival rate for multiple tumours or for BAC cases of different histological types.
The incidence of BAC, which occurs relatively frequently among women, and exhibits a relatively favourable course, has tended to increase in recent years. A majority of these tumours are removed in an early stage. The survival is not significantly poorer in the event of multiple tumours.
细支气管肺泡癌（BAC）是肺腺癌的一种亚型，被认为是不吸烟女性的肺癌。我们研究了BAC的临床特征及其外科治疗方法。
1992年至2001年间，对101例BAC患者进行了肺切除术，其中男性55例，女性46例，平均年龄59.7岁。32例患者不吸烟，69例为现吸烟者。1992年，BAC的发病率占所有腺癌的17.5%，而到2001年已升至51.6%。手术方式包括76例肺叶切除术、12例全肺切除术、11例楔形切除术和2例 exploratory thoracotomies（此处原文有误，推测可能是exploratory thoracotomies，意为探查性开胸手术）。
手术死亡率为0.9%。最终组织学检查结果显示，82.1%的肿瘤处于I期或II期，其中33.7%为I/A期。平均5年生存率为64.3%。女性生存率为75%，明显高于男性的51%（p = 0.045）。多原发肿瘤或不同组织学类型的BAC病例的5年生存率未发现显著差异。
BAC在女性中相对常见，病程相对较好，近年来发病率呈上升趋势。这些肿瘤大多数在早期被切除。多原发肿瘤情况下的生存率并没有明显降低。
