Mickley Frank, Löscher Steffen, Hartmann Andreas
Klinik für Innere Medizin, Städtisches Klinikum "St.Georg", Leipzig, Germany.
Med Klin (Munich). 2004 Jan 15;99(1):18-23. doi: 10.1007/s00063-004-1005-x.
Results of recent studies suggest new aspects in the concept of the management of patients with atrial fibrillation. Current trials comparing rhythm control by cardioversion followed by antiarrhythmic drug therapy with heart rate control only showed that rhythm control was not superior to rate control.
However, some subgroups of patients with frequent or severe symptoms and younger patients with structurally normal hearts may benefit from cardioversion. In patients with persistent atrial fibrillation, sinus rhythm can be restored in approximately 90% by direct current transthoracic cardioversion. Transthoracic cardioversion is effective and safe, if anticoagulation is used. Attempts have been made to improve the success rate by new techniques. However, definition of subgroups and stabilization of sinus rhythm are ongoing issues of debate.
近期研究结果提示心房颤动患者管理理念有新的方面。目前比较通过复律后抗心律失常药物治疗进行节律控制与仅进行心率控制的试验表明,节律控制并不优于心率控制。
然而,一些有频繁或严重症状的患者亚组以及心脏结构正常的年轻患者可能从复律中获益。在持续性心房颤动患者中,通过直流电经胸复律,约90%可恢复窦性心律。如果使用抗凝治疗,经胸复律是有效且安全的。已尝试通过新技术提高成功率。然而,亚组的定义和窦性心律的稳定仍是有争议的问题。