硫酸镁对先兆子痫孕妇视网膜血流的影响：一项随机安慰剂对照研究。
The effect of magnesium sulfate on maternal retinal blood flow in preeclampsia: a randomized placebo-controlled study.
作者信息
Belfort M A, Saade G R, Moise K J
机构信息
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX 77030.
出版信息
Am J Obstet Gynecol. 1992 Dec;167(6):1548-53. doi: 10.1016/0002-9378(92)91737-u.
OBJECTIVES
Our purpose was to determine the effect of a 6 gm intravenous bolus of magnesium sulfate on maternal retinal blood flow velocity waveforms in patients with preeclampsia.
STUDY DESIGN
Twenty-two patients were randomized to two groups and were studied with color flow Doppler before and immediately after infusion of either 6 gm of magnesium sulfate or placebo. The central retinal and posterior ciliary arteries were studied.
RESULTS
Magnesium sulfate significantly reduced the pulsatility index (p < 0.005) in both vessels (change in pulsatility index = 0.26 +/- 0.23 for central retinal and -0.22 +/- 0.15 for posterior ciliary) when compared with placebo (change in pulsatility index = 0.02 +/- 0.10 for central retinal and -0.03 +/- 0.09 for posterior ciliary).
CONCLUSIONS
These data suggest that magnesium sulfate dilates the vessels distal to the central retinal and posterior ciliary arteries. Changes in pulsatility index in the retinal arteries may be indicative of similar changes in other cerebral vessels.
目的
我们的目的是确定静脉推注6克硫酸镁对先兆子痫患者母体视网膜血流速度波形的影响。
研究设计
22名患者被随机分为两组，在输注6克硫酸镁或安慰剂之前及之后立即用彩色多普勒血流仪进行研究。研究了视网膜中央动脉和睫状后动脉。
结果
与安慰剂相比（视网膜中央动脉搏动指数变化=0.02±0.10，睫状后动脉搏动指数变化=-0.03±0.09），硫酸镁显著降低了两条血管的搏动指数（p<0.005）（视网膜中央动脉搏动指数变化=0.26±0.23，睫状后动脉搏动指数变化=-0.22±0.15）。
结论
这些数据表明硫酸镁可扩张视网膜中央动脉和睫状后动脉远端的血管。视网膜动脉搏动指数的变化可能表明其他脑血管也有类似变化。
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