Ding Yong-Bin, Chen Guo-Yu, Xia Jian-Guo, Zang Xi-Wei, Yang Hong-Yu, Yang Li, Liu Yue-Xian
Department of General Surgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
World J Gastroenterol. 2004 Jan 15;10(2):182-5. doi: 10.3748/wjg.v10.i2.182.
To evaluate the tumor-positive ratio and number of perigastric lymph nodes as prognostic factors of gastric carcinoma in surgically-treated patients.
The postoperative survival of 169 patients with gastric cancer who were performed D2 curative gastrectomy was analyzed with regard to its lymph node metastasis ratio and number. Meanwhile correlation of tumor-positive ratio and number of perigastric lymph nodes with pathological parameters of these patients was studied.
The overall 5-year survival rate of all the patients studied was 29.6%. The 5-year cumulative survival rate in patients with 1%-20% and more than 20% of tumor-positive lymph nodes was 70.6% and 12.0% respectively, and 46.6% and 17.4% in those with 1-5 and more than 5 of tumor-positive lymph nodes respectively, which were significantly decreased with the increment of involved lymph nodes assessed by either numbers or ratio (P<0.05). Multiple stepwise regression analysis showed that both the positive ratio and number of tumor-involved lymph nodes were sensitive prognostic factors in these surgically-treated patients, which were also significantly correlated with tumor size and depth of submucosal invasion (P<0.05).
Tumor-positive ratio and number of perigastric lymph nodes are associated with cancer progression and five-year survival rate, and may serve as valuable prognostic factors of gastric cancer in surgically-treated patients.
评估胃周淋巴结的肿瘤阳性率及数量作为手术治疗胃癌患者预后因素的价值。
分析169例行D2根治性胃切除术的胃癌患者术后生存情况与淋巴结转移率及数量的关系。同时研究胃周淋巴结的肿瘤阳性率及数量与这些患者病理参数的相关性。
所有研究患者的总体5年生存率为29.6%。肿瘤阳性淋巴结占1%-20%和超过20%的患者5年累积生存率分别为70.6%和12.0%，肿瘤阳性淋巴结数为1-5个和超过5个的患者分别为46.6%和17.4%，无论按数量还是比例评估，随着受累淋巴结数量的增加，生存率均显著降低（P<0.05）。多因素逐步回归分析显示，肿瘤受累淋巴结的阳性率及数量均是这些手术治疗患者敏感的预后因素，且与肿瘤大小及黏膜下浸润深度显著相关（P<0.05）。
胃周淋巴结的肿瘤阳性率及数量与癌症进展及5年生存率相关，可作为手术治疗胃癌患者有价值的预后因素。
