静脉注射肼苯哒嗪对高血压妊娠母羊肌层子宫内膜和胎盘血流的不同影响。

Differential effects of intravenous hydralazine on myoendometrial and placental blood flow in hypertensive pregnant ewes.

作者信息

Pedron S L, Reid D L, Barnard J M, Henry J B, Phernetton T M, Rankin J H

机构信息

Department of Obstetrics and Gynecology, University of Wisconsin-Madison.

出版信息

Am J Obstet Gynecol. 1992 Dec;167(6):1672-8. doi: 10.1016/0002-9378(92)91760-8.

DOI:10.1016/0002-9378(92)91760-8

PMID:1471685

Abstract

OBJECTIVE

The differential vasoactive effects of hydralazine on the uteroplacental vascular bed were studied.

STUDY DESIGN

After control measurements were taken, near-term chronically prepared pregnant sheep were continuously infused with angiotensin II. Maternal arterial pressure was increased by 32 mm Hg. Hydralazine was then administered; the effects on regional resistance and blood flow were evaluated with a radionuclide-labeled microsphere technique. Analysis of variance for repeated measures was used to compare observations.

RESULTS

When compared with the hypertensive state, hydralazine caused the following changes by 40 minutes (mean +/- SEM): Although maternal blood pressure fell 31% +/- 5% (p = 0.0005), placental blood flow was unchanged, total uteroplacental blood flow increased 24% +/- 8% (p = 0.03), total uteroplacental resistance decreased 43% +/- 4% (p = 0.0002), placental resistance decreased 19% +/- 9% (p = 0.01), myoendometrial blood flow increased 390% +/- 82% (p = 0.0005), and myoendometrial resistance decreased 82% +/- 4% (p = 0.0005).

CONCLUSIONS

In angiotensin II-induced hypertensive ewes, hydralazine is an effective dilator of the uteroplacental vascular bed and can maintain placental blood flow while blood pressure.

摘要

目的

研究肼屈嗪对子宫胎盘血管床的不同血管活性作用。

研究设计

在进行对照测量后，对近期长期准备的妊娠绵羊持续输注血管紧张素II。母体动脉压升高32毫米汞柱。然后给予肼屈嗪；采用放射性核素标记微球技术评估其对局部阻力和血流的影响。使用重复测量方差分析来比较观察结果。

结果

与高血压状态相比，40分钟时肼屈嗪引起以下变化（均值±标准误）：尽管母体血压下降31%±5%（p = 0.0005），但胎盘血流未改变，子宫胎盘总血流增加24%±8%（p = 0.03），子宫胎盘总阻力下降43%±4%（p = 0.0002），胎盘阻力下降19%±9%（p = 0.01），肌层子宫内膜血流增加390%±82%（p = 0.0005），肌层子宫内膜阻力下降82%±4%（p = 0.0005）。