Wu Hong, Wu Daocheng, Yu Kaitao, Feng Xinghua, Yao Zhijun
Department of Chemistry, Faculty of Preclinical Medicine, Fourth Military Medical University, Xi'an 710033.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2003 Dec;20(4):646-9.
Pingyangmycin gelatin microspheres(PYM-GMS) was prepared by optimal double-phase emulsified condensation polymerization for the interventional Chemoembolization with carotid artery therapy, and its release characteristics were studied in vivo and in vitro. The results of three ways of administration(vein drop, artery perfusion and artery embolization) were compared. The experiment indicates that the diameter of PYM-GMS is more appropriate for the application in external carotid artery embolization with PYM-GMS, which significantly reduces the circulating drug level and the dosage, prolongs the time period of higher drug concentration, achieves the purpose of sustained release and targeted tumor therapy.
采用优化的复相乳化凝聚聚合法制备平阳霉素明胶微球（PYM-GMS）用于颈动脉介入化疗栓塞治疗，并对其体内外释药特性进行研究。比较了静脉滴注、动脉灌注和动脉栓塞三种给药方式的效果。实验表明，PYM-GMS的粒径更适合用于PYM-GMS对外颈动脉的栓塞，可显著降低循环血药浓度和用药剂量，延长较高药物浓度的持续时间，达到缓释和靶向肿瘤治疗的目的。
