Izzedine Hassane, Tankere Frederic, Launay-Vacher Vincent, Deray Gilbert
Department of Nephrology, Pitié Salpétrière Hospital, Paris, France.
Kidney Int. 2004 Feb;65(2):369-85. doi: 10.1111/j.1523-1755.2004.00390.x.
The association between ear and kidney anomalies is not usually due to an insult to the embryo. In recent years, many essential development control genes that coordinate the assembly and function of kidney and ear have been discovered through the generation of animal mutants and have increased our understanding of the mechanisms of human oto-renal diseases. Here, we describe ear and kidney clinical syndromes and their molecular expression.
耳与肾异常之间的关联通常并非由胚胎受到损伤所致。近年来，通过构建动物突变体，发现了许多协调肾和耳的组装与功能的重要发育控制基因，这增进了我们对人类耳肾疾病机制的理解。在此，我们描述耳和肾的临床综合征及其分子表达。
