Senior P L, Lavers A
Shell Internationale Petroleum Maatschappij B.V., The Hague, The Netherlands.
Ann Occup Hyg. 1992 Dec;36(6):589-99. doi: 10.1093/annhyg/36.6.589.
The margin of safety is an increasingly important index relating to crop protection products. It relates the available toxicological evidence for the chemical to exposure when the material is used. Determination of potential dermal exposure is an essential element in the calculation of the margin of safety. In the early 1980s a considerable amount of work was done by the British Agrochemicals Association Limited (B.A.A.) on potential dermal exposure. Since that research was undertaken the results obtained have often been used as a model to estimate potential dermal exposure for other crop protection products. This paper presents the findings of a study of potential dermal exposure during boom spraying of an oil-seed rape crop. The conclusions of this study are two-fold. For the application technique studied, the data for mixing and loading generated in the 1980s are inappropriate for prediction of operator exposure and consequent calculation of margin of safety for a product. Also, in future exercises, exposure data should be collected during equipment washing after spraying.
安全系数是与作物保护产品相关的一个日益重要的指标。它将该化学品现有的毒理学证据与材料使用时的暴露情况联系起来。潜在皮肤暴露量的测定是安全系数计算中的一个关键要素。20世纪80年代初,英国农用化学品协会有限公司(B.A.A.)就潜在皮肤暴露量开展了大量工作。自该研究开展以来,所获得的结果常被用作估算其他作物保护产品潜在皮肤暴露量的模型。本文介绍了一项关于油菜作物喷杆喷雾过程中潜在皮肤暴露量研究的结果。这项研究有两个结论。对于所研究的施用技术,20世纪80年代生成的混合和装载数据不适用于预测操作人员的暴露情况以及随后计算产品的安全系数。此外,在未来的试验中,应在喷雾后设备清洗期间收集暴露数据。