Taylor K M
Centre for Health Studies, York University, Ontario, Canada.
Ann Ophthalmol. 1992 Sep;24(9):337-44.
One substudy of the Collaborative Ocular Melanoma Study (COMS) is a randomized trial examining surgery versus radiation therapy for ocular melanoma. To understand the perspective of the physician investigators, a survey of the 101 COMS physicians from 29 major institutions in the United States and Canada was completed before randomization of the first patient. A 95% response rate was obtained, and follow-up interviews were conducted with 87% of the physicians. The study found that (1) COMS physicians identified significant differences between incentives and disincentives to participate in any trial compared with participating in COMS, (2) COMS physicians could be differentiated and had a stronger clinical rather than research orientation, and (3) COMS physicians exhibited a high intention to recruit an identifiable subset of eligible patients. These data suggest that continued support of individual investigators and a close examination of incentives and disincentives to physician participation would be useful in enhancing accrual in this study. A follow-up of this group is planned throughout the anticipated ten-year duration of patient recruitment of this COMS trial.
协作性眼黑色素瘤研究（COMS）的一项子研究是一项随机试验，旨在比较手术与放射治疗对眼黑色素瘤的疗效。为了解参与研究的医生的观点，在第一位患者随机分组之前，对来自美国和加拿大29个主要机构的101位COMS医生进行了一项调查。获得了95%的回复率，并对87%的医生进行了后续访谈。研究发现：（1）与参与COMS相比，COMS医生认为参与任何试验的激励因素和阻碍因素存在显著差异；（2）COMS医生可以被区分，且具有更强的临床导向而非研究导向；（3）COMS医生表现出很高的意愿招募符合条件的特定患者子集。这些数据表明，持续支持个体研究者并仔细审查医生参与研究的激励因素和阻碍因素，将有助于提高该研究的入组率。计划在这项COMS试验预计为期十年的患者招募期间，对该组医生进行随访。
