Loukovaara Mikko, Leinonen Pekka, Teramo Kari, Alfthan Henrik, Stenman Ulf-Håkan, Andersson Sture
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Helsinki, Finland.
Biol Neonate. 2004;85(4):237-42. doi: 10.1159/000076132. Epub 2004 Jan 12.
Maternal diabetes increases the risk of intrauterine hypoxia. Inflammation may play a role in the pathogenesis of hypoxia-related neonatal complications. We studied correlations between levels of cord serum C-reactive protein (CRP), measured by a highly sensitive immunofluorometric assay, and indices of fetal hypoxia in diabetic pregnancies. Cord serum CRP correlated positively with amniotic fluid erythropoietin and umbilical artery pCO2. A negative correlation existed between cord serum CRP and umbilical artery pH and pO2. Amniotic fluid erythropoietin showed an independent effect on cord serum CRP in multiple regression analysis. These data suggest that the fetus responds to hypoxia by an inflammatory reaction.
母体糖尿病会增加子宫内缺氧的风险。炎症可能在缺氧相关新生儿并发症的发病机制中起作用。我们研究了通过高灵敏度免疫荧光测定法测得的脐血血清C反应蛋白（CRP）水平与糖尿病妊娠中胎儿缺氧指标之间的相关性。脐血血清CRP与羊水促红细胞生成素和脐动脉pCO2呈正相关。脐血血清CRP与脐动脉pH和pO2呈负相关。在多元回归分析中，羊水促红细胞生成素对脐血血清CRP有独立影响。这些数据表明，胎儿通过炎症反应对缺氧做出反应。
