Giannetti Luca, Consolo Ugo, Magnoni Cristina, Lo Muzio Lorenzo
Institute of Dentistry and Surgery, Faculty of Medicine, University of Modena, Modena, Italy.
Oncol Rep. 2004 Feb;11(2):401-5.
Apoptosis must be considered a rescue mechanism that controls the integrity of the cell erasing aberrant clones and it is likely that failure of apoptosis constitutes a key factor responsible for tumour formation, progression and resistance to drugs. Several genes (e.g. survivin, bcl-2 family, p53) are involved in these pathways. Much work still needs to be done to identify the molecular pathway of apoptosis resistance but restoration of the apoptotic response represents a crucial new therapeutic target for cancer treatment.
细胞凋亡必须被视为一种控制细胞完整性、消除异常克隆的挽救机制，细胞凋亡的失败很可能是导致肿瘤形成、进展和耐药性的关键因素。几个基因（如生存素、bcl-2家族、p53）参与了这些途径。要确定抗细胞凋亡的分子途径仍有许多工作要做，但恢复细胞凋亡反应是癌症治疗的一个关键新靶点。
