Derman Orhan, Kanbur Nuray Oksöz, Kutluk Tezer
Section of Adolescent Medicine, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara-Turkey.
Int J Adolesc Med Health. 2003 Oct-Dec;15(4):359-63. doi: 10.1515/ijamh.2003.15.4.359.
We evaluated the efficacy of the tamoxifen treatment in 37 patients with pubertal gynecomastia. All had distinct, easily palpable breast swellings with a diameter of over three cm. Pain, tenderness, and swelling associated with gynecomastia were reported by six patients. Eight of the patients were obese. One patient also suffered from varicocele. Pain and size reduction was seen in all patients with tamoxifen treatment. No long-term side effects of tamoxifen were observed. The dose of tamoxifen was increased in three patients due to poor response. Two of the treatment group had recurrence problem at follow-up. We did not need to refer any patient to surgery. Tamoxifen treatment is relatively non-toxic, may be beneficial and we think it should be considered for pubertal gynecomastia.
我们评估了他莫昔芬治疗37例青春期男性乳房发育症患者的疗效。所有患者均有明显的、易于触及的乳房肿胀，直径超过3厘米。6例患者报告有与男性乳房发育症相关的疼痛、压痛和肿胀。8例患者肥胖。1例患者还患有精索静脉曲张。他莫昔芬治疗的所有患者均出现疼痛减轻和乳房尺寸缩小。未观察到他莫昔芬的长期副作用。3例患者因反应不佳增加了他莫昔芬剂量。治疗组中有2例在随访时有复发问题。我们无需将任何患者转诊至手术治疗。他莫昔芬治疗相对无毒，可能有益，我们认为青春期男性乳房发育症应考虑使用该治疗方法。
