Okamoto Akimitsu, Tanaka Kazuo, Saito Isao
Department of Synthetic Chemistry and Biological Chemistry, Faculty of Engineering, Kyoto University, and SORST, Japan Science and Technology Corporation, Kyoto 615-8510, Japan.
J Am Chem Soc. 2004 Jan 21;126(2):416-7. doi: 10.1021/ja038169a.
We have developed a novel nucleosbase, edaG, that efficiently releases various reporter units upon one-electron oxidation. The edaG-selective degradation of ODNs was achieved by various mild oxidizing agents. The oxidant-dependent molecular releasing technique is quite useful not only for DNA-based drug releasing systems but also for the detection of long-range hole transport through DNA without time-consuming analysis.
我们开发了一种新型核碱基edaG，它在单电子氧化后能有效释放各种报告单元。通过各种温和的氧化剂实现了ODNs的edaG选择性降解。这种依赖氧化剂的分子释放技术不仅对基于DNA的药物释放系统非常有用，而且对于无需耗时分析即可检测通过DNA的长程空穴传输也很有用。
