肝素寡糖的合成。
Synthesis of heparin oligosaccharides.
作者信息
Lee Jinq-Chyi, Lu Xin-An, Kulkarni Suvarn S, Wen Yuh-Sheng, Hung Shang-Cheng
机构信息
Department of Chemistry, National Tsing Hua University, Hsinchu 300, Taiwan.
出版信息
J Am Chem Soc. 2004 Jan 21;126(2):476-7. doi: 10.1021/ja038244h.
PMID:14719939
Abstract
An efficient preparation of rare 2-O-benzoyl-3-O-benzyl-1,6-anhydro-beta-l-idopyranose from commercially available diacetone alpha-d-glucose in five straightforward steps is described here. With this key building block in hand, the total syntheses of heparin oligosaccharides with three, five, seven, and nine sugar units are successfully carried out.
摘要
本文描述了一种从市售双丙酮α-D-葡萄糖出发，通过五个简单步骤高效制备稀有2-O-苯甲酰基-3-O-苄基-1,6-脱水-β-L-艾杜吡喃糖的方法。有了这个关键构建单元，成功实现了含三个、五个、七个和九个糖单元的肝素寡糖的全合成。
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