明尼苏达州罗切斯特市1935 - 1989年的强直性脊柱炎。流行病学正在发生变化吗？
Ankylosing spondylitis in Rochester, Minnesota, 1935-1989. Is the epidemiology changing?
作者信息
Carbone L D, Cooper C, Michet C J, Atkinson E J, O'Fallon W M, Melton L J
机构信息
Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota 55905.
出版信息
Arthritis Rheum. 1992 Dec;35(12):1476-82. doi: 10.1002/art.1780351211.
OBJECTIVE
To determine trends in the incidence and clinical presentation of ankylosing spondylitis first diagnosed between 1935 and 1989 among residents of Rochester, Minnesota, and in the survival of the patients.
METHODS
Population-based descriptive study.
RESULTS
The overall age- and sex-adjusted incidence rate was 7.3 per 100,000 person-years (95% confidence interval 6.1-8.4). The rate tended to decline between 1935 and 1989, but there was little change in the age at symptom onset or diagnosis over the 55-year study period. Overall survival was not decreased up to 28 years following diagnosis.
CONCLUSION
These data indicate that there is a constancy in the epidemiologic characteristics of ankylosing spondylitis and suggest that previously study results indicating changes may have been due to biases in patient selection and study design.
目的
确定1935年至1989年首次诊断为强直性脊柱炎的明尼苏达州罗切斯特居民的发病率和临床表现趋势，以及患者的生存率。
方法
基于人群的描述性研究。
结果
年龄和性别调整后的总体发病率为每10万人年7.3例（95%置信区间6.1-8.4）。1935年至1989年期间发病率呈下降趋势，但在55年的研究期间，症状出现或诊断时的年龄变化不大。诊断后长达28年的总体生存率没有下降。
结论
这些数据表明强直性脊柱炎的流行病学特征具有稳定性，并表明先前表明有变化的研究结果可能是由于患者选择和研究设计中的偏差所致。
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