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用于右心室流出道重建的新型异种移植带瓣管道(Contegra)

New xenograft valved conduit (Contegra) for right ventricular outflow tract reconstruction.

作者信息

Chatzis Andrew C, Giannopoulos Nicolas M, Bobos Demetrios, Kirvassilis George B, Rammos Spyros, Sarris George E

机构信息

Department of Paediatric and Congenital Heart Surgery, Onassis Cardiac Surgery Centre, Athens, Greece.

出版信息

Heart Surg Forum. 2003;6(5):396-8.


DOI:
PMID:14721819
Abstract

BACKGROUND: The well-known flaws of existing valved conduits for reconstruction of the right ventricular outflow tract (RVOT) continue to stimulate research for the elusive "perfect" conduit. In this study, we describe our experience with a glutaraldehyde-treated bovine jugular vein valved conduit (Contegra). METHODS: 55 years underwent implantation of a Contegra conduit. Diagnoses/procedures included repair of truncus arteriosus (2 patients), pulmonary atresia (3 patients), severe pulmonary insufficiency after prior repair of tetralogy of Fallot (9 patients), and replacement of degenerated valved conduit (1 patient). RESULTS: No operative deaths occurred. One patient required an early conduit replacement for unexplained valve thrombosis. The early postoperative mean transconduit pressure gradient was 7.7+/- 4.9 mm Hg. At a mean follow-up time of 18.5 +/- 6.9 months, all patients were asymptomatic with no discernible calcification in the valve or conduit or significant valve incompetence, while the mean transvalvular gradient remained low (11.1 +/- 4.5 mm Hg). CONCLUSION: The Contegra valved conduit is well suited for RVOT reconstruction, avoids the use of additional foreign material, and remains well functioning during early followup. Nonetheless, the long-term durability remains to be ascertained.

摘要

背景:用于右心室流出道(RVOT)重建的现有带瓣管道存在的众所周知的缺陷,持续推动着对难以捉摸的“完美”管道的研究。在本研究中,我们描述了我们使用戊二醛处理的牛颈静脉带瓣管道(Contegra)的经验。 方法:55例患者接受了Contegra管道植入。诊断/手术包括动脉干修复(2例患者)、肺动脉闭锁(3例患者)、法洛四联症先前修复术后严重肺动脉瓣关闭不全(9例患者)以及退化带瓣管道置换(1例患者)。 结果:无手术死亡发生。1例患者因不明原因的瓣膜血栓形成需要早期更换管道。术后早期平均跨管道压力阶差为7.7±4.9mmHg。平均随访时间为18.5±6.9个月时,所有患者均无症状,瓣膜或管道无明显钙化,无明显瓣膜关闭不全,而平均跨瓣膜压力阶差仍较低(11.1±4.5mmHg)。 结论:Contegra带瓣管道非常适合RVOT重建,避免使用额外的异体材料,且在早期随访期间功能良好。尽管如此,其长期耐久性仍有待确定。

相似文献

[1]
New xenograft valved conduit (Contegra) for right ventricular outflow tract reconstruction.

Heart Surg Forum. 2003

[2]
Valved bovine jugular vein conduits for right ventricular outflow tract reconstruction in children: an attractive alternative to pulmonary homograft.

Ann Thorac Surg. 2006-9

[3]
The bovine jugular vein: a totally integrated valved conduit to repair the right ventricular outflow.

J Heart Valve Dis. 2002-7

[4]
Right ventricular outflow tract reconstruction using Contegra valved conduit: natural history and conduit performance under pressure.

Eur J Cardiothorac Surg. 2006-3

[5]
Right ventricular outflow tract reconstruction with contegra monocuspid transannular patch in tetralogy of Fallot.

Ann Thorac Surg. 2007-1

[6]
Right ventricular outflow tract reconstruction: what conduit to use? Homograft or Contegra?

Ann Thorac Surg. 2007-8

[7]
The contegra® valved heterograft conduit for right ventricular outflow tract reconstruction: a reliable solution.

Hellenic J Cardiol. 2011

[8]
Repeat right ventricular outflow tract reconstruction using the Medtronic Freestyle porcine aortic root.

J Heart Valve Dis. 2006-1

[9]
Surgery for right ventricle to pulmonary artery conduit obstruction: risk factors for further reoperation.

Eur J Cardiothorac Surg. 2005-8

[10]
Right ventricular outflow tract reconstruction: valved conduit of choice and clinical outcomes.

J Cardiovasc Med (Hagerstown). 2008-4

引用本文的文献

[1]
The Utility of Invengenx® Bovine Patch for Right Ventricular Outflow Tract (RVOT) Reconstruction and Augmentation in the Surgical Management of Tetralogy of Fallot (TOF): A Contemporary Study and Review of the Literature.

Cureus. 2023-10-12

[2]
Individualized Surgical Reconstruction of the Right Ventricle Outflow Tract in Double Outlet Right Ventricle With Mirror Image-Dextrocardia.

Front Pediatr. 2021-2-19

[3]
Contegra conduit for reconstruction of the right ventricular outflow tract: a review of published early and mid-time results.

J Cardiothorac Surg. 2008-11-18

[4]
Ross operation in children and young adults: the Alder Hey case series.

BMC Cardiovasc Disord. 2004-4-19

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