Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase?
作者信息
Smiley James R
机构信息
Department of Medical Microbiology & Immunology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2.
出版信息
J Virol. 2004 Feb;78(3):1063-8. doi: 10.1128/jvi.78.3.1063-1068.2004.
Abstract
摘要
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Herpes simplex virus virion host shutoff protein: immune evasion mediated by a viral RNase?单纯疱疹病毒病毒体宿主关闭蛋白：由病毒核糖核酸酶介导的免疫逃避？
J Virol. 2004 Feb;78(3):1063-8. doi: 10.1128/jvi.78.3.1063-1068.2004.
2
The virion host shutoff RNase plays a key role in blocking the activation of protein kinase R in cells infected with herpes simplex virus 1.病毒宿主关闭核糖核酸酶在阻断单纯疱疹病毒 1 感染细胞中蛋白激酶 R 的激活方面发挥着关键作用。
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Early shutoff of host protein synthesis in cells infected with herpes simplex viruses.单纯疱疹病毒感染的细胞中宿主蛋白合成的早期关闭。
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The nuclear-cytoplasmic shuttling of virion host shutoff RNase is enabled by pUL47 and an embedded nuclear export signal and defines the sites of degradation of AU-rich and stable cellular mRNAs.病毒宿主关闭核糖核酸酶的核质穿梭是由 pUL47 和嵌入式核输出信号介导的，它决定了富含 AU 和稳定的细胞 mRNA 的降解部位。
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Selective degradation of mRNAs by the HSV host shutoff RNase is regulated by the UL47 tegument protein.单纯疱疹病毒（HSV）宿主关闭核糖核酸酶（RNase）对 mRNAs 的选择性降解受 UL47 衣壳蛋白调节。
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Tristetraprolin Recruits the Herpes Simplex Virion Host Shutoff RNase to AU-Rich Elements in Stress Response mRNAs To Enable Their Cleavage.Tristetraprolin招募单纯疱疹病毒体宿主关闭核糖核酸酶至应激反应mRNA中的富含AU元件，以实现其切割。
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本文引用的文献
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Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo.2型单纯疱疹病毒病毒体宿主关闭蛋白在体内原发性感染期间调节α/β干扰素，但不调节适应性免疫反应。
J Virol. 2003 Sep;77(17):9337-45. doi: 10.1128/jvi.77.17.9337-9345.2003.
2
Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells.浆细胞样树突状细胞通过Toll样受体9介导对单纯疱疹病毒2的识别。
J Exp Med. 2003 Aug 4;198(3):513-20. doi: 10.1084/jem.20030162.
3
The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.应激诱导的即时早期反应基因IEX-1在感染单纯疱疹病毒1的细胞中被激活，但包括其RNA的3'降解在内的几种病毒机制会阻止该基因的表达。
J Virol. 2003 Jun;77(11):6178-87. doi: 10.1128/jvi.77.11.6178-6187.2003.
4
Human cytomegalovirus activates inflammatory cytokine responses via CD14 and Toll-like receptor 2.人巨细胞病毒通过CD14和Toll样受体2激活炎性细胞因子反应。
J Virol. 2003 Apr;77(8):4588-96. doi: 10.1128/jvi.77.8.4588-4596.2003.
5
ICP27 interacts with SRPK1 to mediate HSV splicing inhibition by altering SR protein phosphorylation.ICP27与SRPK1相互作用，通过改变SR蛋白磷酸化来介导单纯疱疹病毒剪接抑制。
EMBO J. 2003 Apr 1;22(7):1608-19. doi: 10.1093/emboj/cdg166.
6
Deletion of the virion host shutoff protein (vhs) from herpes simplex virus (HSV) relieves the viral block to dendritic cell activation: potential of vhs- HSV vectors for dendritic cell-mediated immunotherapy.从单纯疱疹病毒（HSV）中删除病毒体宿主关闭蛋白（vhs）可解除病毒对树突状细胞激活的阻滞：vhs缺失型HSV载体用于树突状细胞介导的免疫治疗的潜力。
J Virol. 2003 Mar;77(6):3768-76. doi: 10.1128/jvi.77.6.3768-3776.2003.
7
A subpopulation of tegument protein vhs localizes to detergent-insoluble lipid rafts in herpes simplex virus-infected cells.被膜蛋白vhs的一个亚群定位于单纯疱疹病毒感染细胞中对去污剂不敏感的脂筏。
J Virol. 2003 Feb;77(3):2038-45. doi: 10.1128/jvi.77.3.2038-2045.2003.
8
Varicella-zoster virus (VZV) ORF17 protein induces RNA cleavage and is critical for replication of VZV at 37 degrees C but not 33 degrees C.水痘带状疱疹病毒（VZV）ORF17蛋白诱导RNA裂解，对VZV在37℃而非33℃下的复制至关重要。
J Virol. 2002 Nov;76(21):11012-23. doi: 10.1128/jvi.76.21.11012-11023.2002.
9
mRNA degradation by the virion host shutoff (Vhs) protein of herpes simplex virus: genetic and biochemical evidence that Vhs is a nuclease.单纯疱疹病毒的病毒体宿主关闭（Vhs）蛋白介导的mRNA降解：Vhs是一种核酸酶的遗传学和生物化学证据。
J Virol. 2002 Sep;76(17):8560-71. doi: 10.1128/jvi.76.17.8560-8571.2002.
10
Cell surface major histocompatibility complex class II proteins are regulated by the products of the gamma(1)34.5 and U(L)41 genes of herpes simplex virus 1.细胞表面主要组织相容性复合体II类蛋白受单纯疱疹病毒1型γ(1)34.5和U(L)41基因产物的调控。
J Virol. 2002 Jul;76(14):6974-86. doi: 10.1128/jvi.76.14.6974-6986.2002.
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