超声内镜引导下胰腺光动力治疗：一项初步研究。
EUS-guided photodynamic therapy of the pancreas: a pilot study.
作者信息
Chan Hoi-Hung, Nishioka Norman Shizuaki, Mino Mari, Lauwers Gregory Yves, Puricelli William Peter, Collier Kerry Naomi, Brugge William Robert
机构信息
Gastrointestinal Unit, Gastrointestinal Pathology, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
出版信息
Gastrointest Endosc. 2004 Jan;59(1):95-9. doi: 10.1016/s0016-5107(03)02361-7.
BACKGROUND
Photodynamic therapy of pancreatic cancer by using percutaneously placed light catheters has been reported. The feasibility and safety of EUS-guided photodynamic therapy of the pancreas was studied in a porcine model.
METHODS
After injection of porfimer sodium, a 19-gauge needle was inserted into the pancreas, the liver, the spleen, and the kidney under EUS guidance. A small diameter quartz optical fiber was passed through the EUS needle and used to illuminate the tissue with laser light. The tissue response to photodynamic therapy was examined.
RESULTS
Localized tissue necrosis was achieved in all organs, without significant complication. There was no significant difference in inflammation induced by photodynamic therapy within the various organs.
CONCLUSIONS
EUS-guided photodynamic therapy is a safe and simple technique that can induce small areas of focal tissue ablation within the liver, the pancreas, the kidney, and the spleen, and potentially could be used to treat a variety of benign and malignant conditions.
背景
已有报道采用经皮放置光导管对胰腺癌进行光动力治疗。在猪模型中研究了超声内镜引导下胰腺光动力治疗的可行性和安全性。
方法
注射卟吩姆钠后，在超声内镜引导下将一根19号针插入胰腺、肝脏、脾脏和肾脏。一根小直径石英光纤穿过超声内镜针，用于用激光照射组织。检查组织对光动力治疗的反应。
结果
所有器官均实现了局部组织坏死，无明显并发症。光动力治疗在各器官内引起的炎症无显著差异。
结论
超声内镜引导下的光动力治疗是一种安全、简单的技术，可在肝脏、胰腺、肾脏和脾脏内诱导小面积的局灶性组织消融，并有可能用于治疗各种良性和恶性疾病。
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