Bmi1、干细胞与衰老调控
Bmi1, stem cells, and senescence regulation.
作者信息
Park In-Kyung, Morrison Sean J, Clarke Michael F
机构信息
Department of Internal Medicine, University of Michigan, School of Medicine, Ann Arbor, 48109, USA.
出版信息
J Clin Invest. 2004 Jan;113(2):175-9. doi: 10.1172/JCI20800.
Abstract
Stem cells generate the differentiated cell types within many organs throughout the lifespan of an organism and are thus ultimately responsible for the longevity of multicellular organisms. Therefore, senescence of stem cells must be prevented. Bmi1 is required for the maintenance of adult stem cells in some tissues partly because it represses genes that induce cellular senescence and cell death.
摘要
在生物体的整个生命周期中，干细胞产生许多器官内的分化细胞类型，因此最终对多细胞生物的长寿负责。因此，必须防止干细胞衰老。Bmi1在某些组织中对成体干细胞的维持是必需的，部分原因是它抑制诱导细胞衰老和细胞死亡的基因。
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