Kovacsovics-Bankowski M, Carini C, Kashala O, Essex M
Harvard School of Public Health, Department of Cancer Biology, Boston, Massachusetts.
Viral Immunol. 1992 Winter;5(4):243-8. doi: 10.1089/vim.1992.5.243.
Individuals infected with human immunodeficiency virus type 1 (HIV-1) develop a humoral immune response to the virus's major structural gene products env, gag, and pol. The distribution of antibodies to env, gag, and pol proteins in Central African populations is of interest as they have a high level of immune system activation compared to non-African populations. Using the Western blot technique, we analyzed the isotypic distribution of anti-HIV antibodies in 45 HIV-1-infected individuals from Central Africa that were either symptomatic or asymptomatic. We observed two basic differences between the isotypic profile of individuals from Central Africa and non-African populations. Central African individuals had a strong polyisotypic response to gag and pol, which has only been observed for gag in American and European populations. In addition, individuals from Central Africa had a high frequency of IgG4 to gag and pol, 75 and 51%, respectively, as compared to 29 and 6% in a non-African population. The elevated IgG4 response may result from the high basal level of immune stimulation seen in Africans due to multiple and frequent exposures to viral, bacterial, and parasitic antigens.
感染人类免疫缺陷病毒1型（HIV-1）的个体对该病毒的主要结构基因产物env、gag和pol会产生体液免疫反应。中非人群中针对env、gag和pol蛋白的抗体分布情况备受关注，因为与非非洲人群相比，他们的免疫系统激活水平较高。我们采用蛋白质印迹技术，分析了45名来自中非的有症状或无症状的HIV-1感染者体内抗HIV抗体的同种型分布。我们观察到中非个体与非非洲人群在同种型谱方面存在两个基本差异。中非个体对gag和pol有强烈的多同种型反应，而这种反应仅在美国和欧洲人群的gag中观察到。此外，中非个体中针对gag和pol的IgG4频率较高，分别为75%和51%，而非非洲人群中这一比例分别为29%和6%。IgG4反应升高可能是由于非洲人因多次频繁接触病毒、细菌和寄生虫抗原而出现较高的基础免疫刺激水平所致。
