Fontaine Pierre
Service d'endocrinologie et diabétologie, CHRU de Lille, clinique Marc Linquette, 59037 Lille.
Rev Prat. 2003 Nov 15;53(17):1894-9.
Gestational diabetes represents 6% of all pregnancies and appears even in women without risk factors. This is in favour of a systematic screening between 24th and 28th weeks of gestation. There is as yet still no consensus concerning screening and diagnosis criteria but in France the guidelines are a two step approach: an O'Sullivan test > or = 7.15 mmol/L and a 100 g oral glucose tolerance test (OGTT). Gestational diabetes is defined by 2 or more abnormal values of the OGTT (Carpenter and Coustan criterias). Gestational diabetes has feto-maternal implications: on the one hand gravid hypertension and caesarean section, on the other hand macrosomia, respiratory distress and metabolic complications. The therapeutic management is first diet but insulin therapy is necessary in 40% of cases to obtain glycemic control. During the second part of pregnancy, to obtain a normoglycaemia can decrease and even normalise the rate of feto-maternal complications. Long-term management of women with gestational diabetes and treatment modalities also require better definition, since these patients are at risk for diabetes, mainly type 2. Diabetologists have to set prevention programs up.
妊娠期糖尿病占所有妊娠的6%,甚至在没有危险因素的女性中也会出现。这支持在妊娠24至28周之间进行系统筛查。关于筛查和诊断标准尚无共识,但在法国,指南采用两步法:奥沙利文试验≥7.15 mmol/L以及100克口服葡萄糖耐量试验(OGTT)。妊娠期糖尿病由OGTT的2个或更多异常值定义(卡彭特和库斯坦标准)。妊娠期糖尿病对母婴有影响:一方面是妊娠高血压和剖宫产,另一方面是巨大儿、呼吸窘迫和代谢并发症。治疗管理首先是饮食,但40%的病例需要胰岛素治疗以实现血糖控制。在妊娠后期,实现血糖正常化可降低甚至使母婴并发症发生率正常化。妊娠期糖尿病女性的长期管理和治疗方式也需要更明确的定义,因为这些患者有患糖尿病的风险,主要是2型糖尿病。糖尿病专家必须制定预防计划。