Brosvic G M, Doty R L, Rowe M M, Harron A, Kolodiy N
Department of Psychology, Rider College, Lawrenceville, New Jersey 08648-3099.
Behav Neurosci. 1992 Dec;106(6):992-8. doi: 10.1037//0735-7044.106.6.992.
The influences of hypothyroidism on behavioral measures of the taste function in male and female Long-Evans rats were determined. Experimental rats' preferences for and ability to detect NaCl, HCl, sucrose, and quinine sulfate were examined before, during, and after 9 weeks of maintenance on 0.1% propylthiouracil (PTU), an agent that produces marked hypothyroidism, with similar determinations made for control animals. Despite significant decreases in PTU-treated rats' serum triiodothyronine (T3) and thyroxin (T4), there were no changes in sensitivity or responsivity to the target tastants. However, altered preferences for NaCl, HCl, and quinine sulfate were observed for PTU-treated rats; elevated consumption of HCl and quinine sulfate was present at the end of the study when serum T3 and T4 had returned to near-baseline levels. The data confirm observations that PTU-induced hypothyroidism alters rats' taste preference behavior.
研究了甲状腺功能减退对雄性和雌性长爪沙鼠味觉功能行为指标的影响。在给实验大鼠喂食0.1%丙硫氧嘧啶（PTU，一种可导致明显甲状腺功能减退的药物）9周之前、期间和之后，检测了它们对氯化钠、盐酸、蔗糖和硫酸奎宁的偏好和检测能力，同时对对照动物进行了类似的测定。尽管PTU处理的大鼠血清三碘甲状腺原氨酸（T3）和甲状腺素（T4）显著降低，但对目标味觉物质的敏感性或反应性没有变化。然而，观察到PTU处理的大鼠对氯化钠、盐酸和硫酸奎宁的偏好发生了改变；在研究结束时，当血清T3和T4恢复到接近基线水平时，盐酸和硫酸奎宁的摄入量增加。数据证实了PTU诱导的甲状腺功能减退会改变大鼠味觉偏好行为的观察结果。
