Stearns S B, Benzo C A
Horm Metab Res. 1978 Jan;10(1):20-3. doi: 10.1055/s-0028-1093473.
An inappropriate molar ratio of circulating insulin to glucagon is frequently associated with the metabolic alterations accompanying diabetes mellitus. Plasma immunoreactive insulin (IRI) and immunoreactive glucagon (IRG) levels were determined and the IRG:IRI ratio calculated at various intervals in overt diabetes in genetically diabetic (db/db) and in streptozotocin-treated mice. Plasma IRI levels in genetic mutants are elevated at nine weeks of age, but are comparable to values found in lean littermates by 21 weeks. The presence of a prevailing hyperglucagonemia is established for the first time in the intact db/db mice. Streptozotocin diabetics are found to have characteristically low plasma IRI and high plasma IRG values. The hormonal imbalance present in these two experimental animal models is accentuated when the data are expressed as the IRG:IRI ratio, which is seen to increase with the progression of diabetes.
循环胰岛素与胰高血糖素的摩尔比不当常常与糖尿病伴随的代谢改变相关。在遗传性糖尿病（db/db）小鼠和链脲佐菌素处理的小鼠的显性糖尿病中，于不同时间间隔测定血浆免疫反应性胰岛素（IRI）和免疫反应性胰高血糖素（IRG）水平，并计算IRG:IRI比值。基因变异小鼠的血浆IRI水平在9周龄时升高，但到21周时与瘦的同窝小鼠的值相当。首次在完整的db/db小鼠中证实存在普遍的高胰高血糖素血症。发现链脲佐菌素诱导的糖尿病小鼠具有典型的低血浆IRI和高血浆IRG值。当将数据表示为IRG:IRI比值时，这两种实验动物模型中存在的激素失衡会更加明显，且该比值会随着糖尿病的进展而增加。
