Deshpande U R, Joseph L J, Samuel A M
Radiation Medicine Centre (B. A. R. C.), Tata Memorial Hospital Annexe, Parel, Mumbai 400 012.
Indian J Physiol Pharmacol. 2003 Jul;47(3):332-6.
This study was carried out to see the hepatobiliary clearance of 99m Tc-Mebrofenin radiopharmaceutical in D-galactosamine induced hepatic rats. Furthermore, protective effect of turmeric extract has been studied in these hepatitis rats. Hepatitis was induced with intraperitoneal injection of D-galactosamine (400 mg/kg b. wt) in these rats. 1% turmeric extract was given along with their normal diet for 15 days. Turmeric extract treatment significantly increased the hepatic uptake of radioactivity and accelerated the excretion of 99m Tc-Mebrofenin as compared to control rats. (P < 0.001). In D-galactosamine administered rats, a significant delay was observed in 99m Tc-Mebrofenin excretion as compared to controls. However, D-galactosamine administered rats, pretreated with turmeric extract or concurrently treated with turmeric extract showed a near normal pattern of 99m Tc-Mebrofenin excretion. Hence, it can be suggested that turmeric extract may improve the liver function by detoxification.
本研究旨在观察99m锝-美罗芬宁放射性药物在D-半乳糖胺诱导的肝损伤大鼠中的肝胆清除情况。此外，还研究了姜黄提取物对这些肝炎大鼠的保护作用。通过向这些大鼠腹腔注射D-半乳糖胺（400 mg/kg体重）诱导肝炎。在正常饮食的同时给予1%的姜黄提取物，持续15天。与对照大鼠相比，姜黄提取物治疗显著增加了肝脏对放射性的摄取，并加速了99m锝-美罗芬宁的排泄。（P < 0.001）。与对照组相比，给予D-半乳糖胺的大鼠在99m锝-美罗芬宁排泄方面观察到明显延迟。然而，预先用姜黄提取物处理或同时用姜黄提取物处理的给予D-半乳糖胺的大鼠显示出接近正常的99m锝-美罗芬宁排泄模式。因此，可以认为姜黄提取物可能通过解毒来改善肝功能。
