环ADP核糖类似物：腺苷2'-或3'-甲氧基对构象的影响
cADPR analogues: effect of an adenosine 2'- or 3'-methoxy group on conformation.
作者信息
Graham Steven M, Macaya Daniel J, Sengupta Raghuvir N, Turner Kevin B
机构信息
Department of Chemistry, St. John's University, Jamaica, New York 11439, USA.
出版信息
Org Lett. 2004 Jan 22;6(2):233-6. doi: 10.1021/ol036152r.
PMID:14723536
Abstract
[structure: see text] The 2'-OMe-A (2) and 3'-OMe-A (3) analogues of the calcium release agent cADPR (1) were prepared and their solution structures studied by NMR spectroscopy. Compared to 1, 2 shows a shift in its A ring conformation and changes in its R ring N:S and gammat:gamma+ ratios, while 3 displays a significant change in the conformation of its A ring gamma-bond.
摘要
[结构：见正文] 制备了钙释放剂cADPR（1）的2'-OMe-A（2）和3'-OMe-A（3）类似物，并通过核磁共振光谱研究了它们的溶液结构。与1相比，2的A环构象发生了变化，其R环的N:S和γt:γ+比值也发生了变化，而3的A环γ键构象有显著变化。
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