Hallem Elissa A, Nicole Fox A, Zwiebel Laurence J, Carlson John R
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA.
Nature. 2004 Jan 15;427(6971):212-3. doi: 10.1038/427212a.
Female Anopheles mosquitoes, the world's most important vector of Plasmodium falciparum malaria, locate their human hosts primarily through olfactory cues, but the molecular mechanisms that underlie this recognition are a mystery. Here we show that the Anopheles gambiae protein AgOr1, a female-specific member of a family of putative odorant receptors, responds to a component of human sweat. Compounds designed to activate or block receptors of this type could function as attractants for trapping mosquitoes or as insect repellents in helping to control Anopheles and other insect pests.
雌性按蚊是世界上恶性疟原虫最重要的传播媒介，它们主要通过嗅觉线索来定位人类宿主，但这种识别背后的分子机制仍是个谜。在这里，我们表明冈比亚按蚊蛋白AgOr1是一种假定气味受体家族的雌性特异性成员，它对人类汗液的一种成分有反应。设计用于激活或阻断这类受体的化合物可以作为诱捕蚊子的引诱剂，或者作为驱虫剂来帮助控制按蚊和其他害虫。
