Corti S, Sicher D, Regli W, Stephan R
Institut für Lebensmittelsicherheit und -hygiene, Universität Zürich.
Schweiz Arch Tierheilkd. 2003 Dec;145(12):571-5. doi: 10.1024/0036-7281.145.12.571.
100 strains of Staphylococcus aureus (S. aureus), 100 strains of coagulase-negative staphylococci (CNS), 100 strains of Streptococcus spp. and 100 strains of Escherichia coli (E. coli), isolated from bovine mastitis milk samples between November 2002 and April 2003, were tested for their sensitivity to various antibiotics by means of the agar diffusion method. The antibiotics were chosen on the basis of their licenses for intramammary application in Switzerland (www.vetpharm.unizh.ch). 91% of the S. aureus strains were sensitive to all the antibiotics tested. Only 9% of the strains were resistant to Penicillin G and 7% to Ampicillin. 53% of the CNS strains were sensitive to all the antibiotics tested. 31% exhibited resistance to Penicillin G, 26% to Ampicillin, 16% to Cloxacillin and 14% to Lincomycin. 30% of the Streptococcus spp. strains were sensitive to all the antibiotics tested. 4% were resistant to Penicillin G, 4% to Amoxicillin/clavulanic acid, 1% to Cefoperazone, 2% to Cefquinome, 35% to Neomycin, 22% to Gentamicin, 61% to Kanamy-cin and 11% to Lincomycin. 43% of the strains showed multiple resistance. 79% of the E. coli strains were sensitive to all the antibiotics tested. 20% exhibited resistance to Ampicillin, 9% to Neomycin and 10% to Kanamycin. A comparison of the own results with data of other authors in Switzerland shows no important changes in the resistance situation during the last 20 years. With the exception of two strains (Streptococcus spp.), all tested isolates were sensible against Cefquinome.
2002年11月至2003年4月期间,从患有乳腺炎的奶牛乳汁样本中分离出100株金黄色葡萄球菌、100株凝固酶阴性葡萄球菌、100株链球菌属细菌和100株大肠杆菌,采用琼脂扩散法检测它们对各种抗生素的敏感性。这些抗生素是根据其在瑞士用于乳房内给药的许可情况选定的(www.vetpharm.unizh.ch)。91%的金黄色葡萄球菌菌株对所有测试抗生素敏感。只有9%的菌株对青霉素G耐药,7%对氨苄西林耐药。53%的凝固酶阴性葡萄球菌菌株对所有测试抗生素敏感。31%对青霉素G耐药,26%对氨苄西林耐药,16%对氯唑西林耐药,14%对林可霉素耐药。30%的链球菌属细菌菌株对所有测试抗生素敏感。4%对青霉素G耐药,4%对阿莫西林/克拉维酸耐药,1%对头孢哌酮耐药,2%对头孢喹肟耐药,35%对新霉素耐药,22%对庆大霉素耐药,61%对卡那霉素耐药,11%对林可霉素耐药。43%的菌株表现出多重耐药性。79%的大肠杆菌菌株对所有测试抗生素敏感。20%对氨苄西林耐药,9%对新霉素耐药,10%对卡那霉素耐药。将自己的结果与瑞士其他作者的数据进行比较,结果显示在过去20年中耐药情况没有重大变化。除两株(链球菌属细菌)外,所有测试分离株对头孢喹肟均敏感。