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[根据EUROASPIRE I-II研究的匈牙利数据看千禧年之交冠心病的二级预防]

[Secondary prevention of coronary disease--at the turn of the millennium in light of the Hungarian data of the EUROASPIRE I-II. Studies].

作者信息

Ostör Erika, Jánosi András, Adám Zsófia, Bárczy György, Borbás Sarolta, Dávid Beáta, Gallai Istvánné, Podmaniczky Márta, Ruzsányi Tivadarné

机构信息

Szt. János Kórház, III. Belgyógyászat, Kardiológia, Budapest.

出版信息

Orv Hetil. 2003 Dec 7;144(49):2399-404.

Abstract

UNLABELLED

Relevant national societies attribute special importance to the secondary prevention of coronary patients. This is well formulated in their recommendations (9, 11). Actual clinical practice was studied in 1995-1996 by the EUROASPIRE I study. Its Hungarian data were published in 1999 (8). The scope of EUROASPIRE II in 1999-2000 was to study changes occurred in these 5 years. In this paper the authors intend to answer the question whether the clinical practice of secondary prevention of coronary patients showed any changes at the turn of the millennium. Participating centres, the criteria of patient selection and the applied methods were identical in the two studies. Hospital data of 516 patients below the age of 70 were analysed. There was no difference between the two studies neither in the distribution according to gender and age, nor in the number of death. Documentation of the relevant data in the hospital records improved substantially: blood pressure was registered in every patient chart, lipid values in 91%. Information on smoking however is still missing in 1/3 of the patients, while on weight and height in half of them. The response rate at the follow up investigation on was 75%. The prevalence of obesity increased by 60%, that of smoking by 13% since the first investigation 5 years ago. This rate of increase is the largest among the 9 participating centres. The prevalence of hypertension decreased by 24.5% and the proportion of hypertensive patients receiving treatment increased by 7%. In spite of these blood pressure values over 140/90 mmHg were found in 37% of the patients. The mean triglyceride value increased by 53% and the prevalence of severe hypercholesterolaemia by 43%. Lipid lowering drugs are given to 51% of the patients in contrast to 22% 5 years earlier. In spite of this cholesterol values above 5.5 mmol/l were found in 42%. In respect of prophylactic drugs the proportion of patients receiving beta blockers increased from 58 to 84%.

INTERPRETATION

The evaluation of complex risk of patients and their long-term care is still deficient. Drug treatment improved quantitatively but not qualitatively. This and the lack of lifestyle-improving medical efforts is reflected by the increase of the proportion of obese and smoking patients and the persistently high prevalence of hypercholesterolaemia and hypertension.

摘要

未标注

相关国家学会特别重视冠心病患者的二级预防。这在他们的建议中得到了很好的阐述(9, 11)。欧洲动脉粥样硬化患病率及干预研究I(EUROASPIRE I)于1995 - 1996年对实际临床实践进行了研究。其匈牙利的数据于1999年发表(8)。欧洲动脉粥样硬化患病率及干预研究II(EUROASPIRE II)在1999 - 2000年的研究范围是调查这5年中发生的变化。在本文中,作者旨在回答在千年之交冠心病患者二级预防的临床实践是否有任何变化这一问题。两项研究的参与中心、患者选择标准及应用方法均相同。分析了516例70岁以下患者的医院数据。两项研究在按性别和年龄的分布以及死亡人数方面均无差异。医院记录中相关数据的记录有了显著改善:每位患者病历中均记录了血压,91%记录了血脂值。然而,仍有1/3的患者缺少吸烟信息,一半患者缺少体重和身高信息。随访调查的应答率为75%。自5年前首次调查以来,肥胖患病率增加了60%,吸烟患病率增加了13%。这一增长率在9个参与中心中是最高的。高血压患病率下降了24.5%,接受治疗的高血压患者比例增加了7%。尽管如此,仍有37%的患者血压值超过140/90 mmHg。平均甘油三酯值增加了53%,重度高胆固醇血症患病率增加了43%。51%的患者服用降脂药物,而5年前这一比例为22%。尽管如此,仍有42%的患者胆固醇值高于5.5 mmol/l。在预防性药物方面,接受β受体阻滞剂治疗的患者比例从58%增至84%。

解读

对患者综合风险的评估及其长期护理仍存在不足。药物治疗在数量上有所改善,但质量上没有。肥胖和吸烟患者比例的增加以及高胆固醇血症和高血压的持续高患病率反映了这一点以及改善生活方式的医疗努力的缺乏。

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