Jackson J E
Department of Transfusion Medicine, Leicester Royal Infirmary, Infirmary Square, Leicester LE1 5WW, UK.
Br J Biomed Sci. 2003;60(4):227-32. doi: 10.1080/09674845.2003.11783705.
Transfusion of blood products carries the risk of pathogen transmission, despite careful donor selection and screening tests. This is due to viral transmission from window-period donations, the emergence of new pathogens such as variant Creutzfeldt-Jakob disease, for which routine screening tests are not yet available, and to bacterial contamination. Techniques have been developed to inactivate pathogens in both fresh frozen plasma and platelet concentrates. The relative benefits to the recipient, and the ease of incorporation into blood component processing are considered for the technologies currently available.
尽管对献血者进行了仔细筛选并进行了筛查测试，但输注血液制品仍存在病原体传播的风险。这是由于窗口期献血导致的病毒传播、诸如变异型克雅氏病等新病原体的出现（目前尚无针对此类病原体的常规筛查测试）以及细菌污染。已经开发出了在新鲜冰冻血浆和血小板浓缩物中灭活病原体的技术。目前可用的技术会考虑对受血者的相对益处以及融入血液成分加工过程的难易程度。
