Bhatnagar Sunil Kumar, Paul George, Subramanian Raghavan, Al Hosni Mohammad S, Al Khusaiby Saleh Mohamed
Paediatric Infectious Diseases Unit, Division of Child Health, The Royal Hospital, Ministry of Health, Sultanate of Oman.
J Trop Pediatr. 2003 Dec;49(6):361-6. doi: 10.1093/tropej/49.6.361.
A total of 39 patients were diagnosed to have Kawasaki disease by the standard diagnostic criteria, at The Royal Hospital, Muscat, Oman, during the period January 1995 to August 2002. A retrospective analysis of the case records of the patients with the diagnosis of Kawasaki disease was done. The results of the clinical features and the laboratory manifestations of the patients, who are from the Middle East region, are presented. The peak age at presentation was 6-30 months, mean 29 months. Peak months of the occurrence of the disease were March and October. Oral lesions were found in all cases. The mean duration of hospital stay for these patients was 8.5 days, range 2-21 days. The total duration of fever ranged from 6 to 21 days, with a mean value of 9.4 days. An elevated erythrocytic sedimentation rate (ESR; 91.7 per cent) and a raised C-reactive protein (C-RP; 92.3 per cent) were the most significant laboratory findings. Echocardiographic abnormalities were found in 25 per cent of cases, the incidence of coronary artery involvement (dilatation with or without stenosis) being 12.5 per cent. High dose intravenous immunoglobulin (2 g/kg over a 12-h period) plus aspirin therapy was found to be safe and effective in patients with Kawasaki disease.
1995年1月至2002年8月期间，阿曼马斯喀特皇家医院共有39例患者根据标准诊断标准被诊断为川崎病。对诊断为川崎病的患者病历进行了回顾性分析。呈现了来自中东地区患者的临床特征和实验室检查结果。发病的高峰年龄为6 - 30个月，平均29个月。发病的高峰月份为3月和10月。所有病例均发现口腔病变。这些患者的平均住院时间为8.5天，范围为2 - 21天。发热总时长为6至21天，平均值为9.4天。红细胞沉降率升高（ESR；91.7%）和C反应蛋白升高（C-RP；92.3%）是最显著的实验室检查结果。25%的病例发现有超声心动图异常，冠状动脉受累（扩张伴或不伴狭窄）的发生率为12.5%。发现大剂量静脉注射免疫球蛋白（12小时内2 g/kg）加阿司匹林治疗对川崎病患者安全有效。
