Meloche Sylvain, Vella Francis D J, Voisin Laure, Ang Siew-Lan, Saba-El-Leil Marc
Institut de Recherche en Immunovirologie et Cancérologie, Université de Montréal, Montréal, Québec Canada.
Cell Cycle. 2004 Mar;3(3):241-3. Epub 2004 Mar 1.
Differentiation of the mammalian blastocyst generates two distinct cell lineages: the trophectoderm, which contributes to the trophoblast layers of the placenta, and the inner cell mass, which forms the embryo. We and others recently demonstrated that the MAP kinase ERK2 is essential for trophoblast development. Erk2 mutant embryos fail to form extra-embryonic ectoderm and the ectoplacental cone, suggesting a role for ERK2 activation in the proliferation of trophoblast stem (TS) cells. Previous studies have documented that ERK1/2 activity is dispensable for proliferation of embryonic stem (ES) cells and rather interferes with self-renewal. Thus, signaling by the ERK1/2 MAP kinase pathway appears to be critical for the regulation of self-renewal and propagation of early embryo stem cell populations.
滋养外胚层，它形成胎盘的滋养层；以及内细胞团，它形成胚胎。我们和其他人最近证明，丝裂原活化蛋白激酶ERK2对滋养层发育至关重要。Erk2突变胚胎无法形成胚外外胚层和外胎盘锥，这表明ERK2激活在滋养层干细胞（TS）增殖中发挥作用。先前的研究表明，ERK1/2活性对于胚胎干细胞（ES）的增殖并非必需，反而会干扰自我更新。因此，ERK1/2丝裂原活化蛋白激酶途径的信号传导似乎对早期胚胎干细胞群体的自我更新和增殖调节至关重要。
