Rifle Gérard, Hervé Patrick
UPRES EA563, Faculté de Médecine, Université de Bourgogne and Department of Nephrology-Intensive Care-Transplantation, Hôpital du Bocage, Dijon, France.
Transplantation. 2004 Jan 15;77(1 Suppl):S5. doi: 10.1097/01.TP.0000107184.18562.FC.
Among the mechanisms capable of inducing peripheral tolerance, regulatory (suppressor) T cells (Treg) probably play a key role in the control of both reactivity to self-antigens and alloimmune response. Augmentation or manipulation of Treg could improve organ allograft survival or control graft-versus-host disease, thus resulting in operational tolerance. The role of this immunomanipulation as one method of inducing tolerance has yet to be clearly defined.
在能够诱导外周耐受的机制中，调节性（抑制性）T细胞（Treg）可能在控制自身抗原反应性和同种免疫反应方面发挥关键作用。增强或调控Treg可提高器官移植存活率或控制移植物抗宿主病，从而实现操作性耐受。这种免疫调控作为诱导耐受的一种方法，其作用尚未明确界定。
